Source: Compiled by DCAT Value Chain Insights editorial staff using company information. These are the results of an analysis of the key financial figures for the financial years 2017, 2018 and 2019 for the 21 largest pharmaceutical companies in the world prepared by the auditing and consulting firm EY. Jarvis L.M. Adding capabilities in cell and gene therapy production has also been a target of certain contract development and manufacturing organizations/contract manufacturing organizations (CDMOs/CMOs). The fragmentation of the EU pharmaceutical market has resulted in a lucrative parallel trade. It is a significant contributor to global API and intermediate manufacturing. Europe represents the second largest pharmaceutical market in the world and was valued at US$219.9 billion in 2019. The profit margins are high, there are a large number of small and large sized player, and strict government regulations make it a very competitive industry. Last year (August 2018), Mylan, a generic-drug company, formed a strategic review committee to evaluate alternatives for its businesses following weak performance in its North American segment. | 2019;97:33–37. Structure of tenapanor, trifarotene, and pitolisant. 10,342 crore (US$ 1.47 billion). 2018 FDA drug approvals. www.dcat.org, 2019: The Pharmaceutical Industry Year in Review, Drug, Chemical & Associated Technologies Association (DCAT), Bristol-Myers Squibb’s $74-billion acquisition of Celgene, AbbVie’s pending $63-billion acquisition of Allergan, Takeda’s $62-billion acquisition of Shire, The pending combination of Mylan and Pfizer’s generics and off-patent business to form Viatris, Investment in cell and gene therapies—pharma companies, Investment in cell and gene therapies capabilities—CDMOs/CMOs. The transaction is expected to close in the first quarter of 2020. Zejula is approved in the US and Europe as a treatment for adult patients with recurrent ovarian cancer who are in response to platinum-based chemotherapy, regardless of BRCA mutation or biomarker status. 9. COVID-19 is an emerging, rapidly evolving situation. This is a PESTEL analysis of the pharmaceutical industry analyzing how these various pressures affect it. The EMA issued a vacancy notice with the Official Journal of the European Union earlier this year (May 2019) for the position of Executive Director as the term of the current EMA Executive Director, Guido Rasi, is set to come to an end in November 2020. In a much-debated move, the European Union adopted earlier this year (2019) manufacturing waivers to supplementary protection certificates (SPCs), a move supported by generics and biosimilars producers and active pharmaceutical ingredient (API) manufacturers. Throughout the Brexit process, the UK pharmaceutical industry has maintained a position of the importance of the UK securing a deal to exit the EU, which has seen two missed deadlines for withdrawal: the original withdrawal date of March 29, 2019, an extended withdrawal date of October 31, 2019, and now a further extension provided by the EU to the UK until January 31, 2020. One Union St., Suite 208 Borchers AT, Hagie F, Keen CL, Gershwin ME. While mega mergers dominated the news in 2019, several pharmaceutical companies made key smaller acquisitions to build their pipelines and commercial portfolios. Molecules. Structure of enfortumab vedotin and polatuzumab vedotin. Global Pharmaceutical Logistics Market Analysis 2015-2019 and Forecast 2020-2025. It is now facing direct biosimilar competition in Europe and other countries, which represent approximately 75% of AbbVie's international Humira business or approximately 25% of total global Humira revenues, according to AbbVie’s annual 2018 financial filing. We couldn’t find any significant Legal factors affecting the pharmaceutical industry. The pharmaceutical industry has been one of the more controversial industries in the United States primarily due to high drug prices. In US too, the industry is under intense pressures. 2009 Dec;8(12):959-68. doi: 10.1038/nrd2961. Nat. Earlier this year (2019), Novartis acquired CELLforCURE, a CDMO of cell and gene therapies in Europe, from LFB, a French pharmaceutical company. Vision 2030: Indian pharmaceutical industry aspires to be ~120-130 Bn USD and largest volume producer in the world CAGR 7-8% CAGR 11-12% Projected size of the Indian pharma market, USD billion SOURCE: IQVIA, AIOCD, Pharmexcil, IPA Team analysis, secondary research Accelerate universal health care across India by access to eCollection 2020 May. Findings from our analysis of transcripts from investor calls for 38 biopharma companies found that between Q4 2019 and Q1 2020, statements continue to focus on consumers and profit (figure 2). Structure of Trikafta TM , a drug combination (in green the structure of…. Pfizer remains the top industry prescription sales leader.Revenues and R&D of Top Pharma Companies As 2019 comes to a close, what were the top news stories shaping the pharmaceutical industry? During December 2019, on moving annual total (MAT) basis, industry growth was at 9.8%, price growth was at 5.3%, new product growth was at 2.7%, and volume growth was at two% y-o-y. In August 2019, Pfizer reported that it is investing an additional $500 million in the construction of its gene-therapy manufacturing facility in Sanford, North Carolina. | In August 2019, Mylan and Pfizer agreed to combine Mylan with Upjohn, Pfizer’s off-patent branded and generic established medicines business, to form a new pharmaceutical company. During 2019, the US Food and Drug Administration (FDA) approved 48 new drugs (38 New Chemical Entities and 10 Biologics). Inclisiran is a small interfering RNA (siRNA) therapy being studied to evaluate its ability to lower LDL-C. Now Johnson faces the same issue as he awaits a general election on December 12, 2019, designed as a vote of confidence and signal of support for his Brexit deal. http://www.accessdata.fda.gov/scripts/cder/daf/, Blue SKies/National of Research Foundation. For its part, Pfizer has been evaluating possible separation of its generics and established product business dating back to when the company was led by Ian Read, who stepped down as Chief Executive Officer (CEO) earlier this year (January 2019) with Albert Bourla, formerly the Chief Operating Officer of Pfizer, taking the role of CEO. Structures of drugs containing trifluoromethyl…. Indian pharmaceutical sector industry supplies over 50 per cent of global demand for various vaccines, 40 per cent of generic demand in the US and 25 per cent o... September 24, 2019 : Indian Pharmaceuticals Industry Analysis An upcoming date of importance for trade negotiations between the US and China is December 15, when US tariffs are set to rise, and as the two sides work to avoid that increase in a Phase-One deal that would guarantee China’s purchases of US agricultural goods and exactly which tariffs to roll back under a new deal. 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